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SML1548

Sigma-Aldrich

THPN

≥98% (HPLC)

Synonym(s):

1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200

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About This Item

Empirical Formula (Hill Notation):
C15H22O4
CAS Number:
100079-26-3
Molecular Weight:
266.33
UNSPSC Code:
12352200
PubChem Substance ID:
329825957
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1

InChI

1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3

InChI key

NVFRHTFJDGAFQS-UHFFFAOYSA-N

General description

THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.

Biochem/physiol Actions

THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.

Other Notes

air sensitive

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L et al
Nature Chemical Biology, 11(5), 339-346 (2015)

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