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SML1623

Sigma-Aldrich

MSP-3

≥98% (HPLC)

Synonym(s):

N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide

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About This Item

Empirical Formula (Hill Notation):
C16H19NO3S
CAS Number:
1820968-63-5
Molecular Weight:
305.39
UNSPSC Code:
12352200
PubChem Substance ID:
329825508
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

oil

color

white to beige

storage temp.

room temp

SMILES string

O=C(NCC1=CC=C(O)C(OC)=C1)CCCC2=CC=CS2

InChI

1S/C16H19NO3S/c1-20-15-10-12(7-8-14(15)18)11-17-16(19)6-2-4-13-5-3-9-21-13/h3,5,7-10,18H,2,4,6,11H2,1H3,(H,17,19)

InChI key

HCUVEUVIUAJXRB-UHFFFAOYSA-N

Biochem/physiol Actions

MSP-3 is a Transient Receptor Potential Vanilloid Type-1 (TRPV1) channel agonist with antioxidant and neuroprotective activity. MSP-3 activated TRPV1 channels with similar efficacy as compared to capsaicin (EC50 = 870 nM). It protected a keratinocyte cell line from oxidative stress damage with more efficacy than capsaicin and prevented the damage caused by H2O2 in differentiated human neuroblastoma cell lines as well as in rat cortical slices.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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