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SML1813

Sigma-Aldrich

Ani9

Synonym(s):

(4-Chloro-2-methylphenoxy)-acetic acid [(2-methoxyphenyl)methylene]hydrazide, 2-(4-Chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide, 2-(4-Chloro-2-methylphenoxy)-acetic acid 2-[(2-methoxyphenyl)methylene]hydrazide

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About This Item

Empirical Formula (Hill Notation):
C17H17ClN2O3
CAS Number:
356102-14-2
Molecular Weight:
332.78
UNSPSC Code:
12352200
PubChem Substance ID:
329826081
NACRES:
NA.77

assay

≥98% (HPLC)

Quality Level

100

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=C(OCC(NN=CC2=C(OC)C=CC=C2)=O)C=CC(Cl)=C1

Application

Ani9 has been used to find out the inappropriate modulation of the membrane protein functions that are involved in the 198 ADGRG2- or Gq-mediated regulation of fluid reabsorption in the efferent ductules.

Biochem/physiol Actions

2-(4-chloro-2-methylphenoxy)-N-[(2-methoxyphenyl)methylideneamino]-acetamide (Ani9), the most potent inhibitor, is the structural analog of Ani7. It may be considered as a novel candidate for drug therapy of cancer, hypertension, pain, diarrhea and asthma.
Ani9 is a potent and highly selective anoctamin1 (ANO1)/transmembrane protein 16A (TMEM16A) inhibitor that completely inhibited ANO1 chloride current with submicromolar potency. Ani9 does not affect the intracellular calcium signaling and CFTR chloride channel activity.

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ani9, a novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2.
Seo Y, et al.
PLoS ONE, 11(5), e0155771-e0155771 (2016)
Gq activity-and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, et al.
eLife, 7, e33432-e33432 (2018)

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