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SML1902

Sigma-Aldrich

ISAM-140

≥98% (HPLC)

Synonym(s):

(±)-Isopropyl 4-(Furan-2-yl)-2-methyl-1,4-dihydrobenzo-[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate, 4-(2-Furanyl)-4,10-dihydro-2-methyl-pyrimido[1,2-a]benzimidazole-3-carboxylic acid 1-methylethyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H19N3O3
CAS Number:
932191-62-3
Molecular Weight:
337.37
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=C(C(OC(C)C)=O)C(C2=CC=CO2)N3C(N1)=NC4=C3C=CC=C4

Biochem/physiol Actions

ISAM-140 is a potent and selective A2B adenosine receptor antagonist (A2BAR). ISAM-140 exhibits remarkable selectivity over A1, A2A, and A3 adenosine receptors.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Abdelaziz El Maatougui et al.
Journal of medicinal chemistry, 59(5), 1967-1983 (2016-01-30)
Three novel families of A2B adenosine receptor antagonists were identified in the context of the structural exploration of the 3,4-dihydropyrimidin-2(1H)-one chemotype. The most appealing series contain imidazole, 1,2,4-triazole, or benzimidazole rings fused to the 2,3-positions of the parent diazinone core.

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