SML2240
IU1-47
≥98% (HPLC)
Synonym(s):
1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-piperidinyl)ethanone
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About This Item
Empirical Formula (Hill Notation):
C19H23ClN2O
CAS Number:
Molecular Weight:
330.85
MDL number:
UNSPSC Code:
12352200
Recommended Products
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
ClC1=CC=C(N2C(C)=CC(C(CN3CCCCC3)=O)=C2C)C=C1
Biochem/physiol Actions
IU1-47 is a potent and selective inhibitor of the deubiquitinating enzyme UPS14. IU1-47 enhances protein degradation including human wild-type and pathological Tau forms in neurons.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Monica Boselli et al.
The Journal of biological chemistry, 292(47), 19209-19225 (2017-10-04)
The ubiquitin-proteasome system (UPS) is responsible for most selective protein degradation in eukaryotes and regulates numerous cellular processes, including cell cycle control and protein quality control. A component of this system, the deubiquitinating enzyme USP14, associates with the proteasome where
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