SML2397
Dooku1
≥98% (HPLC)
Synonym(s):
2-((2,6-dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
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About This Item
Empirical Formula (Hill Notation):
C13H9Cl2N3OS
CAS Number:
Molecular Weight:
326.20
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
ClC(C=CC=C1Cl)=C1CSC2=NN=C(C3=CC=CN3)O2
Biochem/physiol Actions
Dooku1, an analog of Yoda1, is a potent and selective antagonist of the mechanosensitive Piezo1 channel that inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Elizabeth L Evans et al.
British journal of pharmacology, 175(10), 1744-1759 (2018-03-03)
The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small-molecule agonist, but the pharmacology of these channels is otherwise limited. Yoda1 analogues were generated by synthetic chemistry. Intracellular Ca2+ and Tl+ measurements were made
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