SML2529
MDL-800
≥98% (HPLC)
Synonym(s):
Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate
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About This Item
Empirical Formula (Hill Notation):
C21H16BrCl2FN2O6S2
CAS Number:
Molecular Weight:
626.30
MDL number:
UNSPSC Code:
41116158
NACRES:
NA.77
Recommended Products
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
MDL-800 is a selective allosteric activator of SIRT6, a member of the SIRT deacetylase family that is responsible for deacetylation of histones H3K9Ac and H3K56ac and has tumor suppressor activity. MDL-800 increased the deacetylase activity of SIRT6 by up to 22-fold resulting in a decrease in H3K9Ac and H3K56Ac in hepatocellular carcinoma (HCC) cells, causing cell cycle arrest and inhibiting their proliferation. It also suppressed the growth of xenografts of the hepatocellular carcinoma cell line BEL7405.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Zhimin Huang et al.
Nature chemical biology, 14(12), 1118-1126 (2018-10-31)
SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone H3 Nε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has frequently been found to have low expression in various cancers. Here, we report
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