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SML2650

Sigma-Aldrich

T3-CLK

≥98% (HPLC)

Synonym(s):

4-(2-Methyl-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-N-(6-(pyridin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide, 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide, T3

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About This Item

Empirical Formula (Hill Notation):
C28H30N6O2
CAS Number:
2109805-56-1
Molecular Weight:
482.58
MDL number:
MFCD31689325
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

Biochem/physiol Actions

T3-CLK (T3) is a cell permeable, highly potent and selective cell-base stable inhibitor of CDC-like kinase (CLK) that exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3-CLK increases conjoined gene (CG) transcription.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Tyler Funnell et al.
Nature communications, 8(1), 7-7 (2017-02-25)
CDC-like kinase phosphorylation of serine/arginine-rich proteins is central to RNA splicing reactions. Yet, the genomic network of CDC-like kinase-dependent RNA processing events remains poorly defined. Here, we explore the connectivity of genomic CDC-like kinase splicing functions by applying graduated, short-exposure

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