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SML2683

Sigma-Aldrich

dBET6

≥98% (HPLC)

Synonym(s):

(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

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About This Item

Empirical Formula (Hill Notation):
C42H45ClN8O7S
CAS Number:
1950634-92-0
Molecular Weight:
841.37
MDL number:
MFCD31692407
UNSPSC Code:
12352200
NACRES:
NA.77

ligand

thalidomide

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

dBET6 is a highly cell penetrant, potent and selective BET (bromodomain and extra-terminal domain) degrader that induces rapid (<4hrs) degradation of BRD2, BRD3 and BRD4 and complete down-regulation of c-MYC protein and induction of apoptosis. dBET6 exhibits potent anti-cancer activities.

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wgk_germany

WGK 3

flash_point_f

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flash_point_c

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Certificates of Analysis (COA)

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Georg E Winter et al.
Molecular cell, 67(1), 5-18 (2017-07-05)
Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-limiting event in human gene control. A small number of regulatory factors influence transcription elongation on a global scale. Prior research using small-molecule BET bromodomain inhibitors

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