SML2712
ES9-17
≥98% (HPLC)
Synonym(s):
5-Bromo-2-thiophenesulfonanilide, 5-Bromo-N-phenyl-2-thiophenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C10H8BrNO2S2
CAS Number:
Molecular Weight:
318.21
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O=S(NC1=CC=CC=C1)(C2=CC=C(S2)Br)=O
Biochem/physiol Actions
ES9-17 is a potent and selective inhibitor of clathrin-mediated endocytosis (CME) that binds to N-terminal domain of clathrin heavy chain. ES9-17 inhibits uptake of different endocytic cargoes in Arabidopsis and HeLa cells.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Wim Dejonghe et al.
Nature chemical biology, 15(6), 641-649 (2019-04-24)
Clathrin-mediated endocytosis (CME) is a highly conserved and essential cellular process in eukaryotic cells, but its dynamic and vital nature makes it challenging to study using classical genetics tools. In contrast, although small molecules can acutely and reversibly perturb CME
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