SML2861
FIT-039
≥98% (HPLC)
Synonym(s):
FIT 039, FIT039, N-(5-Fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide, N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide
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About This Item
Empirical Formula (Hill Notation):
C17H18FN3S
CAS Number:
Molecular Weight:
315.41
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
FIT-039 is a potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor that binds to the ATP -binding pocket of CDK9 and inhibits the kinase activity of P-TEFb complex. FIT-039 inhibits replication of herpes simplex virus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured cells. FIT-039 ointment inhibits formation of skin legion in a mice HSV-1 infection model.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Eriko Sumi et al.
Clinical drug investigation, 39(1), 55-61 (2018-10-05)
Cutaneous warts are caused by human papilloma virus (HPV) infection. FIT039, a specific inhibitor of CDK9, suppresses the proliferation of DNA viruses in vitro. We evaluated the safety, plasma concentrations, and efficacy of FIT039 delivered by single application of an
Makoto Yamamoto et al.
The Journal of clinical investigation, 124(8), 3479-3488 (2014-07-09)
A wide range of antiviral drugs is currently available; however, drug-resistant viruses have begun to emerge and represent a potential public health risk. Here, we explored the use of compounds that inhibit or interfere with the action of essential host
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