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SML2907

Sigma-Aldrich

Azumolene

≥98% (HPLC)

Synonym(s):

1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]-2,4-imidazolidinedione, EU 4093

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About This Item

Empirical Formula (Hill Notation):
C13H9BrN4O3
CAS Number:
64748-79-4
Molecular Weight:
349.14
MDL number:
MFCD00867710
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to very dark gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)

InChI key

SEGCNGONCZQFDW-UHFFFAOYSA-N

Biochem/physiol Actions

Azumolene, a more water-soluble analog of dantrolene, is a potent inhibitor of sarcoplasmic reticulum (SR) ryanodine receptor (RyR) that inhibits skeletal muscle SR Ca2+ release. Azumolene is a direct acting skeletal muscle relaxant that induces effective blockade of skeletal muscle RyR1.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Erin E Talbert et al.
PloS one, 11(2), e0148161-e0148161 (2016-02-06)
Mechanical ventilation (MV) is a life-saving intervention for patients in respiratory failure. However, prolonged MV causes the rapid development of diaphragm muscle atrophy, and diaphragmatic weakness may contribute to difficult weaning from MV. Therefore, developing a therapeutic countermeasure to protect

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