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SML2920

Sigma-Aldrich

Y-39983 dihydrochloride

≥98% (HPLC)

Synonym(s):

4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide dihydrochloride, Y 39983, Y39983

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About This Item

Empirical Formula (Hill Notation):
C16H16N4O · 2HCl
CAS Number:
173897-44-4
Molecular Weight:
353.25
MDL number:
MFCD00945328
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +5 to +9°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

N[C@@H](C1=CC=C(C(NC2=CC=NC3=C2C=CN3)=O)C=C1)C.Cl.Cl

InChI

1S/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/m1../s1

InChI key

CKFHAVRPVZNMGT-YQFADDPSSA-N

Biochem/physiol Actions

Y-39983 is a potent and selective Rho-kinase (ROCK) inhibitor (IC50s = 3.6 nM). Y-39983 is 10 fold more potent in promoting the outgrowth of neurites in cultured retinal slices and axonal regeneration in crushed optic nerve models than Y-27632. Y-39983 act also as an activator of the neuroprotective Parkin-mediated mitophagy pathway.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Kevin G Chen et al.
Journal of visualized experiments : JoVE, (89) (2014-08-01)
Human pluripotent stem cells (hPSCs) hold great promise for regenerative medicine and biopharmaceutical applications. Currently, optimal culture and efficient expansion of large amounts of clinical-grade hPSCs are critical issues in hPSC-based therapies. Conventionally, hPSCs are propagated as colonies on both

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