SML2973
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 trifluoroacetate
≥95% (HPLC)
Synonym(s):
N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-valyl-L-leucyl-L-glutaminyl-L-serylglycyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-Lysinamide trifluoroacetate
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About This Item
Empirical Formula (Hill Notation):
C69H99N19O20 · xC2HF3O2
CAS Number:
Molecular Weight:
1514.64 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
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Biochem/physiol Actions
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescence resonance energy transfer (FRET) substrate derived from the N-terminal auto-cleavage fragment of the SARS-CoV Mpro viral protease ((excitation wavelengths 320 nm and emission wavelengths 405 nm). MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is suitable to measure protease activity of COVID-19 virus Mpro, SARS-CoV Mpro, and other viruses.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Xiaoyu Xue et al.
Journal of molecular biology, 366(3), 965-975 (2006-12-27)
The viral proteases have proven to be the most selective and useful for removing the fusion tags in fusion protein expression systems. As a key enzyme in the viral life-cycle, the main protease (M(pro)) is most attractive for drug design
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