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SML3038

Sigma-Aldrich

JB170

≥98% (HPLC)

Synonym(s):

4-((9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[c]pyrimido[4,5-e]azepin-2-yl)amino)-N-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)-2-methoxybenzamide, Thalidomide-PEG2-Alisertib

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About This Item

Empirical Formula (Hill Notation):
C48H44ClFN8O11
CAS Number:
2705844-82-0
Molecular Weight:
963.36
UNSPSC Code:
12352107
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

2-8°C

SMILES string

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C(OCC(NCCOCCOCCNC(C4=CC=C(NC5=NC(C(C=CC(Cl)=C6)=C6C(C7=C(OC)C=CC=C7F)=NC8)=C8C=N5)C=C4OC)=O)=O)=CC=C3)=O

Biochem/physiol Actions

JB170 is a highly specific AURORA-A degrader (PROTAC) comprising aurora kinase inhibitor alisertib connected to the CEREBLON-binding molecule thalidomide. JB170 induces rapid and durable degradation of AURORA-A in cancer cells leading to strong S-phase arrest and apoptosis.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Bikash Adhikari et al.
Nature chemical biology, 16(11), 1179-1188 (2020-09-30)
The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. Although the catalytic activity of AURORA-A is essential for its mitotic function, recent reports indicate an additional non-catalytic function, which is difficult to

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