Skip to Content
MilliporeSigma
All Photos(1)

Documents

SML3115

Sigma-Aldrich

L-690,330

≥98% (HPLC)

Synonym(s):

L 690330, L-690330, P,P′-[1-(4-Hydroxyphenoxy)ethylidene]bis[phosphonic acid], [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H12O8P2
CAS Number:
142523-38-4
Molecular Weight:
298.12
MDL number:
MFCD00673897
UNSPSC Code:
12352107
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

OC1=CC=C(OC(C)(P(O)(O)=O)P(O)(O)=O)C=C1

InChI

1S/C8H12O8P2/c1-8(17(10,11)12,18(13,14)15)16-7-4-2-6(9)3-5-7/h2-5,9H,1H3,(H2,10,11,12)(H2,13,14,15)

InChI key

JKOCAAWWDVHWKB-UHFFFAOYSA-N

Biochem/physiol Actions

L-690,330 is potent and selective competitive inhibitor of inositol inositol monophosphatase (IMPase), which is stable to hydrolysis. Recently L-690,330 used to activate autophagy and protect against alpha-synuclein-induced toxicity in Lund human mesencephalic (LUHMES) neurons without influencing dopaminergic markers.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Matthias Höllerhage et al.
Neuropharmacology, 149, 13-26 (2019-02-08)
Pathological aggregates of alpha-synuclein are the common hallmarks of synucleinopathies, including Parkinson's disease. There is currently no disease-modifying therapy approved for neurodegenerative synucleinopathies. The induction of macroautophagy by small compounds may be a strategy to reduce the cellular alpha-synuclein burden

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service