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SML3118

Sigma-Aldrich

Obatoclax mesylate

≥98% (HPLC)

Synonym(s):

2-(2-((3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole, methanesulfonate salt, GX15-070 mesylate

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About This Item

Empirical Formula (Hill Notation):
C20H19N3O · CH4O3S
CAS Number:
803712-79-0
Molecular Weight:
413.49
MDL number:
MFCD18074508
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

dark green to black

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=S(O)(C)=O.CC1=C(NC(C)=C1)/C=C2N=C(C3=CC4=C(N3)C=CC=C4)C=C\2OC

Biochem/physiol Actions

Obatoclax (GX15–070) is a BH3 domain-targeting inhibitor against Bcl-2 family anti-apoptotic proteins, including A1/Bfl-1, Bcl-2, Bcl-B, Bcl-w, Bcl-XL, and MCL-1. Obatoclax induces cancer cell apoptosis in cultures (0.05-2 μM) and in vivo (1.25-10 mg/kg via im. ip. or iv. in mice) by overcoming Bcl-2 members-mediated resistance to BAX- or BAK-dependent apoptosis.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Skin Irrit. 2

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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