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SML3184

Sigma-Aldrich

Santacruzamate A

≥98% (HPLC)

Synonym(s):

CAY 10683, CAY-10683, CAY10683, N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]carbamic acid ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O3
CAS Number:
1477949-42-0
Molecular Weight:
278.35
MDL number:
MFCD28348356
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1

InChI

1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)

InChI key

HTOYBIILVCHURC-UHFFFAOYSA-N

Biochem/physiol Actions

Santacruzamate A (CAY10683) is a cell-permeable and bioavailable carbamate compound that potently inhibits HDAC2 (IC50 = 119 nM) selectively over HDAC4 and HDAC6 (IC50 = > 1 μM and 433.5 nM, respectively). CAY10683 readily enhances cellular acetylated HDAC2 levels upon LPS-stimulation and only modestly inhibits HuT-78 cutaneous T-cell lymphoma and HCT-116 colon carcinoma cells growth (GI50 = 1.4 and 29.4 uM, respectively). It alleviates acute liver failure (ALF) in rats (i.p.) and rescues cognitive deficits in APPswe/PS1dE9 mice (p.o.).

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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