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SML3299

Sigma-Aldrich

S-Ketorolac

≥98% (HPLC)

Synonym(s):

(-)-Ketorolac, (1S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, (S)-Ketorolac

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About This Item

Empirical Formula (Hill Notation):
C15H13NO3
CAS Number:
66635-92-5
Molecular Weight:
255.27
MDL number:
MFCD00871493
UNSPSC Code:
12352200

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -165 to -185°, c = 0.5 in methanol

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19)/t11-/m0/s1

InChI key

OZWKMVRBQXNZKK-NSHDSACASA-N

Biochem/physiol Actions

S-Ketorolac is an active enantiomer of nonsteroidal anti-inflammatory drug Ketorolac. S-Ketorolac is a selective and potent cyclooxygenase 1/2 (COX-1/2) inhibitor which exhibits anti-inflammatory activities. It is significantly more potent than non-selective COX inhibitors indomethacin or diclofenac.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytoreductive surgery and chemotherapy are cornerstones of ovarian cancer treatment, yet disease recurrence remains a significant clinical issue. Surgery can release cancer cells into the circulation, suppress anti-tumor immunity, and induce inflammatory responses that support the growth of residual disease.

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