SML3371
MS47134
≥98% (HPLC)
Synonym(s):
((1r,3R,5S,7R)-3,5-dimethyladamantane-1-carbonyl)-D-phenylalanine
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About This Item
Empirical Formula (Hill Notation):
C22H29NO3
Molecular Weight:
355.47
UNSPSC Code:
12352200
NACRES:
NA.21
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Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N[C@H](CC1=CC=CC=C1)C(O)=O)[C@]2(C[C@]3(C)C4)C[C@@H]4C[C@](C3)(C)C2
Biochem/physiol Actions
MS47134 is a potent and selective agonist probe of the GPCR orphan receptor MRGPRX4.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Can Cao et al.
Nature, 600(7887), 170-175 (2021-11-19)
The MRGPRX family of receptors (MRGPRX1-4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently1. Of these, MRGPRX2 and MRGPRX4 are key physiological and pathological mediators of itch and related mast cell-mediated hypersensitivity reactions2-5. MRGPRX2 couples to
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