SML3392
BC-11 hydrobromide
≥98% (HPLC)
Synonym(s):
Carbamimidothioic acid (4-boronophenyl)methyl ester hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C8H11BN2O2S·HBr
CAS Number:
Molecular Weight:
290.97
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
−20°C
InChI
1S/C8H11BN2O2S.BrH/c10-8(11)14-5-6-1-3-7(4-2-6)9(12)13;/h1-4,12-13H,5H2,(H3,10,11);1H
InChI key
PAFZAMOVHIRQOD-UHFFFAOYSA-N
Biochem/physiol Actions
BC-11 is a potent and selective inhibitor of urokinase (urokinase-plasminogen activator, uPA). BC-11 inhibits clot lysis with no effect on clot formation. BC-11 exhibits anti-fibrotic activity and improves wound healing and scar quality after topical administration in mice.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Alessandra Longo et al.
Molecules (Basel, Switzerland), 20(6), 9879-9889 (2015-06-02)
BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal to its ED50 at
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