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SML3566

Sigma-Aldrich

SUN11602

≥95% (HPLC)

Synonym(s):

4-[[4-[[2-(4-Amino-2,3,5,6-tetramethylanilino)acetyl]-methylamino]piperidin-1-yl]methyl]benzamide, 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide, SUN 11602, SUN-11602

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About This Item

Empirical Formula (Hill Notation):
C26H37N5O2
CAS Number:
704869-38-5
Molecular Weight:
451.60
MDL number:
MFCD28133375
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic that protects against glutamate toxicity in primary rat cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a rat hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Norihito Murayama et al.
Brain research, 1594, 71-81 (2014-12-03)
Basic fibroblast growth factor (FGF-2/bFGF) possesses neuroprotective activity and promotes cell proliferation. In this study, the novel synthetic compound 4-({4-[[(4-amino-2,3,5,6-tetramethylanilino)acetyl](methyl)amino]-1-piperidinyl}methyl)benzamide (SUN11602) exhibited neuroprotective activities similar to those of FGF-2 without promoting cell proliferation. In primary cultures of hippocampal neurons, stimulation

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