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SML3638

Sigma-Aldrich

Ceftobiprole

≥95% (HPLC)

Synonym(s):

(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-ylidene)- 2-nitroso-1-oxoethyl]amino]-8-oxo-3-[(E)-[2-oxo-1-[(3R)- 3-pyrrolidinyl]-3-pyrrolidinylidene]methyl]-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, BAL 9141, BAL 9141-000, Ro 63-9141

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About This Item

Empirical Formula (Hill Notation):
C20H22N8O6S2
CAS Number:
209467-52-7
Molecular Weight:
534.57
MDL number:
MFCD25976436
UNSPSC Code:
51111800
UNSPSC Code:
12352200
NACRES:
NA.25

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Acidified)

storage temp.

-10 to -25°C

Biochem/physiol Actions

Ceftobiprole is a fifth generation broad spectrum cephalosporin that is active against many resistant bacterial strains including methicillin-resistant Staphylococcus aureus (MRSA). Ceftobiprole inhabits PBP1 (penicillin-binding protein 1), PBP2 and ß-lactam resistance determinant PBP2a.

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gunnar T R Hischebeth et al.
Diagnostic microbiology and infectious disease, 91(2), 175-178 (2018-02-18)
Antibiotic therapy is essential in foreign body associated infections. The treatment regime should aim at high tissue concentrations, high bioavailability, high biofilm penetration and good tolerance. We investigated whether the new cephalosporin ceftobiprole is active against clinical isolates from musculoskeletal
Impact of PBP4 Alterations on ?-Lactam Resistance and Ceftobiprole Non-Susceptibility Among Enterococcus faecalis Clinical Isolates
Lazzaro LM, Cassisi M, Stefani S, Campanile F
Frontiers in Cellular and Infection Microbiology, 11, 816657-816657 (2022)

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