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SRP0386

Sigma-Aldrich

NSD1 human

recombinant, expressed in E. coli, ≥63% (SDS-PAGE)

Synonym(s):

KMT3B, STO, nuclear receptor binding SET domain protein 1

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥63% (SDS-PAGE)

form

aqueous solution

mol wt

54 kDa

packaging

pkg of 50 μg

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... NSD1(64324)

General description

Human NSD1 (GenBank Accession No. NM_022455), amino-acids 1849-2094 with N-terminal GST tag, MW = 54 kDa, expressed in an E.coli expression system.

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Pascale Saugier-Veber et al.
Human mutation, 28(11), 1098-1107 (2007-06-15)
Sotos syndrome is an overgrowth syndrome characterized by distinctive facial features, learning difficulties, and macrocephaly with frequent pre- and postnatal overgrowth with advanced bone age. Here, we report on our experience in the molecular diagnostic of Sotos syndrome on 116
Toshiko Yamada-Okabe et al.
Cell biochemistry and function, 26(2), 146-150 (2007-04-18)
Nuclear receptor-binding SET-domain-containing protein 1 (NSD1), a culprit gene for Sotos syndrome, contains a su(var)3-9, enhancer-of-zeste, trithorax (SET) domain that is responsible for histone methyltransferase activity and other domains such as plant homeodomain (PHD) and proline-tryptophan-tryptophan-proline (PWWP) involved in protein-protein

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