SRP2102
TNFα, low endotoxin, His tagged human
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Synonym(s):
DIF, TNF-alpha, TNFA, TNFSF2
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.26
Recommended Products
biological source
human
recombinant
expressed in E. coli
assay
≥80% (SDS-PAGE)
form
frozen liquid
mol wt
~21 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
1250 μg/mL
color
clear colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... TNF(7124)
General description
Tumor necrosis factor α (TNFα or TNFSF2) is encoded by the gene mapped to human chromosome 6p21.33.
Biochem/physiol Actions
Tumor necrosis factor α (TNFα or TNFSF2) is produced by many different cell types including activated monocytes, fibroblasts, endothelial cells, macrophages, T-cells, B-lymphocytes, granulocytes, smooth muscle cells, eosinophilis, chondrocytes and other cell types. It functions as a cytokine involved in cell proliferation, differentiation, apoptosis, lipid metabolism and coagulation. High level of TNFα leads to the development of inflammatory responses that are hallmarks of many diseases including autoimmune diseases, insulin resistance and cancer. The active form of TNFα (18 kDa) is generated by the cleavage of an Ala-Val bond between residues 76-77 of the precursor protein.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Bharat B Aggarwal
Nature reviews. Immunology, 3(9), 745-756 (2003-09-02)
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins
Alasdair J Edgar et al.
Respiratory research, 7, 1-1 (2006-01-05)
To elucidate further the pathogenesis of sporadic, idiopathic pulmonary arterial hypertension (IPAH) and identify potential therapeutic avenues, differential gene expression in IPAH was examined by suppression subtractive hybridisation (SSH). Peripheral lung samples were obtained immediately after removal from patients undergoing
A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.
Bos SD
European Journal of Human Genetics, 18, 953-959 (2010)
Hao Zhu et al.
Frontiers in cell and developmental biology, 9, 642437-642437 (2021-03-26)
Low back pain is tightly associated with intervertebral disc degeneration (IVDD) and aberrant nucleus pulposus (NP) is a critical cause. miRNAs N6-methyladenosine (m6A) modification accounts for the TNF-α-induced senescence of NP cells. The aim of this study was to investigate
The TNF and TNF receptor superfamilies: integrating mammalian biology.
R M Locksley et al.
Cell, 104(4), 487-501 (2001-03-10)
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