SRP3263
G-CSF human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
CSF-3, GM-CSF?, MGI-1G, pluripoietin
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
10.0-25.0 ng/mL
mol wt
18.7 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CSF3(1440)
Related Categories
General description
Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. Human and murine G-CSF are cross-species reactive. The gene encoding G-CSF is localized on human chromosome 17. Recombinant human G-CSF is an 18.7kDa protein consisting of 174 amino acid residues.
Biochem/physiol Actions
Granulocyte colony stimulating factor (G-CSF) or colony stimulating factor 3 (CSF-3) is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It controls the production, differentiation and function of granulocytes. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. The protein has been shown to have a role in bone repair in animal models and clinically approved for neutropenia treatment.
Physical form
Lyophilized from 5 mM Sodium Citrate, pH 4.0.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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