SRP4011
Cardiotrophin-1 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
CT1, CTF1, Cardiophin 1
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About This Item
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biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~22.5 kDa
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CTF1(1489)
General description
Cardiotrophin-1 belongs to the interleukin-6 (IL-6) family of cytokines. It is a cytoprotective protein. The gene is mapped to human chromosome 16p11.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.
Biochem/physiol Actions
Cardiotrophin-1 signals via β receptor glycoprotein 130 (gp130) and β receptor leukemia inhibitory factor receptor (LIFR). It confers protective role on cardiac myocytes. Cardiotrophin-1 protects cardiomyocytes from cell death, however, it can also induce cardiac hypertrophy. It is also involved in neural tissue development and helps in protection of the mature nervous system from injuries and dysfunction. Cardiotrophin-1 also protects liver against injury. It is also involved in the control of body weight and intermediate metabolism. In mouse model, it protects β cells from apoptosis. It also promotes glucose-mediated insulin secretion. Absence of the cardiotrophin-1 gene in mice is associated with obesity, hyperglycemia, hyperinsulinemia and hypercholesterolemia.
Physical form
Sterile filtered and then lyophilized in 1 x PBS.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 20 mM Tris, pH 8.0 to a concentration of <1.0 mg/mL. The solution can be diluted into other aqueous buffers.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.
Lutz SZ, et al.
PLoS ONE, 9, e100391-e100391 (2014)
Cardiotrophin-1: A multifaceted cytokine.
Lopez-Yoldi M, et al.
Cytokine & Growth Factor Reviews, 26, 523-523 (2015)
Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.
Hung HC, et al.
Scientific Reports, 5, 17438-17438 (2015)
Alejandro Aranda et al.
Cellular and molecular life sciences : CMLS, 71(23), 4637-4651 (2014-05-06)
We report a new method to generate high-expressing mammalian cell lines in a quick and efficient way. For that purpose, we developed a master cell line (MCL) containing an inducible alphavirus vector expressing GFP integrated into the genome. In the
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