SRP6003
Procalcitonin human
recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
Synonym(s):
CALC1, CALCA, CGRP, Calcitonin
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About This Item
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biological source
human
recombinant
expressed in E. coli
assay
≥97% (HPLC)
≥97% (SDS-PAGE)
form
lyophilized
potency
80 ng/mL
mol wt
12.796 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
Endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... N/A(796)
General description
The gene CALC1 (calcitonin 1) is mapped to human chromosome 11. CALC1 encodes for preprocalcitonin. Preprocalcitonin is cleaved by endopeptidase at the amino-terminal to produce procalcitonin. Procalcitonin works as a peptide hormone and is mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Recombinant human procalcitonin produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons.
Application
Procalcitonin human has been used in in vitro vascular permeability assay.
Biochem/physiol Actions
Procalcitonin is a prohormone of calcitonin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. Procalcitonin is also associated with systemic complications in humans suffering from acute pancreatitis.
Physical form
Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Nana-Maria Wagner et al.
Anesthesia and analgesia, 124(3), 836-845 (2016-09-23)
Procalcitonin is used as a diagnostic tool for the identification and risk stratification of septic patients. Procalcitonin plasma concentrations tightly correlate with the severity of the ongoing inflammatory reaction and can rise up to 10,000-fold. Impairment of endothelial cell function
Physiology and genetics of procalcitonin.
Maruna P
Physiological Research, 49, S57-S61 (2000)
The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis.
Rau B
Gut, 41, 832-832 (1997)
Procalcitonin as an acute phase marker.
Annals of Clinical Biochemistry, 38, 483-493 (2001)
High serum procalcitonin concentrations in patients with sepsis and infection.
Lancet, 341, 515-518 (1993)
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