SRP6370
Aldolase A human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Synonym(s):
ALDA, ALDOA, Fructose bisphosphate Aldolase A, GSD12
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
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biological source
human
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
liquid
mol wt
41.5 kDa (384 aa, 1-364 aa + His Tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ALDOA(226)
General description
Aldolase A (ALDOA) is a ubiquitous glycolytic enzyme expressed in developing embryos and in adult muscles. The gene encoding it is localized on human chromosome 16p11.2. Recombinant human Aldolase A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Biochem/physiol Actions
In glycolysis, aldolase A (ALDOA) catalyzes the reversible reaction of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. It is involved in a wide range of cellular functions such as maintenance of striated muscle contraction, cell shape and mobility, actin filament organization and ATP biosynthetic process. High expression level of ALDOA is reported in various forms of malignant cancers, including human lung squamous, renal cell and hepatocellular carcinomas. ALDOA deficiency causes myopathy and hemolytic anemia.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl and 10% glycerol.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Two cases of red cell aldolase deficiency associated with hereditary hemolytic anemia in a Japanese family.
Miwa S
American Journal of Hematology, 11(4) (1981)
Association and Mutation Analyses of 16p11.2 Autism Candidate Genes
Ravinesh A
PLoS ONE (2009)
Human aldolase A deficiency associated with a hemolytic anemia: thermolabile aldolase due to a single base mutation.
Kishi H
Proceedings of the National Academy of Sciences of the USA, 84(23) (1987)
Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.
Sha Du
PLoS ONE, 9(9) (2014)
Comparative proteomics analysis of gastric cancer stem cells.
Morisaki T
PLoS ONE, 9(14) (2014)
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