SRP6508
Haptoglobin (Phenotype 2-2) from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Hp 2-2
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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General description
Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.
Application
Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.
Biochem/physiol Actions
Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.
Physical form
Lyophilized as a salt-free solid.
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males
Michel R L, et al.
Clinical Chemistry, 46, 1619?1625-1619?1625 (2000)
Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage
Chaichana K, et al.
Stroke, 38(12), 3266-3271 (2007)
The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
Rinkoo D, et al.
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease, 13(5), 373?376-373?376 (2016)
Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype
Atkinson S, et al.
PLoS Medicine, 3(5), e172-e172 (2006)
Mi-Kyung Oh et al.
PloS one, 17(5), e0266409-e0266409 (2022-05-18)
Transforming growth factor-β (TGF-β) is an important inducer of the epithelial-to-mesenchymal transition (EMT) in various cancers. Our previous study demonstrated that prohaptoglobin (proHp) stimulates Smad1/5 activation via ALK1, a TGF-β type I receptor, in endothelial cells, suggesting that proHp plays
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