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SRP6509

Sigma-Aldrich

Chymotrypsin from human pancreas

≥95% (SDS-PAGE)

Synonym(s):

CLCR, CTRC, CTRC_HUMAN, Caldecrin, Chymotrypsin C, Chymotrypsin-C, ELA 4, Elastase 4, Elastase IV, Serum calcium decreasing factor

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About This Item

EC Number:
232-671-2
UNSPSC Code:
12352204
NACRES:
NA.78

biological source

human

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

25 kDa

packaging

pkg of 100 μg

UniProt accession no.

Q99895

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CTRC(11330)

Related Categories

General description

Chymotrypsin from human pancreas is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. It is secreted by the pancreas as inactive chymotrypsinogen C. Molecular weight of this enzyme is found to be 25kDa. The pI is 8.75.

Biochem/physiol Actions

Chymotrypsin from human pancreas selectively hydrolyzes peptide bonds on the C-terminal side of tyrosine, phenylalanine, tryptophan and leucine. Loss-of-function mutations in this gene have been associated with increased risk of chronic pancreatitis. It has high activity toward leucyl peptide bonds. The enzyme acts as a co-activator of procarboxypeptidases A1 and A2.

Physical form

Lyophilized as a salt-free solid.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Szabo A
The Journal of Biological Chemistry, 290(28), 17282-17292 (2015)

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