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SRP8041

Sigma-Aldrich

LAG-3 (mouse): FC (mouse)

recombinant, expressed in CHO cells, >95% (SDS-PAGE)

Synonym(s):

ACEH, FDC protein, Lymphocyte activation gene-3

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

mouse

recombinant

expressed in CHO cells

assay

>95% (SDS-PAGE)

form

liquid

mol wt

monomer ~180 kDa by SDS-PAGE (non-reducing)
monomer ~80 kDa by SDS-PAGE (reducing)

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

≥0.2 mg/mL

impurities

<1 EU/μg endotoxin, tested

color

clear

UniProt accession no.

Q61790

shipped in

wet ice

storage temp.

−20°C

Gene Information

mouse ... Lag3(16768)

General description

Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

Physical form

Solution in PBS.

Other Notes

The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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