T1705
Anti-TDP-43 antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ALS10, Anti-TARDBP, Anti-TARDP43, Anti-Tar DNA binding protein 43
Sign Into View Organizational & Contract Pricing
All Photos(3)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~43 kDa
species reactivity
human, rat, mouse
concentration
~1.5 mg/mL
technique(s)
immunohistochemistry: 5-10 μg/mL using rat, mouse or human kidney
indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells
western blot: 1.5-3.0 μg/mL using human U2OS cell lysates
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TARDBP(23435)
General description
TDP-43 (TAR DNA binding protein, TARDP) is encoded by the gene mapped to human chromosome 1p36.22. The encoded protein belongs to the family of heterogenous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is a 414 amino acid nuclear protein and is widely expressed in a variety of tissues.
Specificity
Anti-TDP-43 specifically recognizes human, mouse, and rat TDP-43.
Biochem/physiol Actions
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are involved in the generation and processing of RNA, including transcription, splicing, transport and stability. TDP-43 regulates transcription of human immunodeficiency virus (HIV). The protein is identified as a major pathological protein, in both frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS). Abnormal phosphorylation of TDP-43 at Ser409/410 has also been observed in FTLD-U and ALS, suggesting a toxic gain of function leading to apoptosis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Matthew J G Eldridge et al.
PLoS pathogens, 17(12), e1010173-e1010173 (2021-12-21)
For many intracellular bacterial pathogens manipulating host cell survival is essential for maintaining their replicative niche, and is a common strategy used to promote infection. The bacterial pathogen Listeria monocytogenes is well known to hijack host machinery for its own
Miao Sun et al.
Journal of neuroscience research, 92(1), 54-63 (2013-11-23)
The 43-kDa transactivation response DNA binding protein (TDP43), fused in sarcoma/translocated in liposarcoma (FUS/TLS), heat shock protein 70 (HSP70), and β-amyloid (Aβ) are induced and involved in cerebral ischemia, amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), but their relationships
Rodger Wilhite et al.
Future science OA, 3(4), FSO238-FSO238 (2017-11-15)
Alzheimer's disease (AD) and other forms of dementia create a noncurable disease population in world's societies. To develop a blood-based biomarker is important so that the remedial or disease-altering therapeutic intervention for AD patients would be available at the early
The role of TDP-43 in amyotrophic lateral sclerosis and frontotemporal dementia
Mackenzie, Ian RA and Rademakers, Rosa
Current Opinion in Neurology, 21(6), 693-693 (2008)
Jack L Pinkus et al.
Neuromuscular disorders : NMD, 24(7), 611-616 (2014-05-27)
Previous histopathologic studies of sporadic inclusion body myositis (sIBM) identified sarcoplasmic aggregation and myonuclear depletion of the predominantly nuclear heterogeneous nuclear ribonucleoprotein (hnRNP) TDP-43 in sIBM myofibers. Here, we examined sIBM muscle for abnormalities in two other hnRNPs hnRNPA1 and
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service