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T2027

Sigma-Aldrich

Anti-Transferrin antibody produced in goat

whole antiserum

Synonym(s):

Anti-HEL-S-71p, Anti-PRO1557, Anti-PRO2086, Anti-TFQTL1

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About This Item

MDL number:
MFCD00162555
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

indirect ELISA: 1:50,000
quantitative precipitin assay: 3.2-4.8 mg/mL

UniProt accession no.

P02787

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TF(7018)

Related Categories

General description

Transferrin is a bilobed glycoprotein. The polypeptide chain of transferrin is composed of two homologous lobes i.e N- and C- lobes. Each lobe is made of two domains N1, N2 and C1, C2 which are linked by a hinge. It has two specific sites for binding of Fe3+.

Application

Anti-Transferrin antibody has been used:
  • in quantitative precipitin assay
  • in enzyme linked immunosorbent assay (ELISA)
  • in western blotting
  • in immunoblotting

Anti-Transferrin antibody produced in goat was used in western blotting analysis of HEK293 cell extracts.

Biochem/physiol Actions

Transferrin is the major iron transporter protein that binds Fe(+3). The transferring-iron import system consists of a TonB dependent transporter (TbpA), and a lipoprotein co-receptor (TbpB) and both proteins work together in the transport of iron across the membrane.
Transferrin plays a major role in providing iron as a source for haemoglobin synthesis. It binds to the transferrin receptor 1(TfR1).

Preparation Note

treated to remove lipoproteins

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Cole P Anderson et al.
Biochimica et biophysica acta, 1823(9), 1468-1483 (2012-05-23)
Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein involved in iron uptake, storage, utilization and export. Over the
New iron acquisition system in Bacteroidetes
Manfredi P, et al.
Infection and Immunity, 83(1), 300-310 (2015)
Nicholas Noinaj et al.
Molecular microbiology, 86(2), 246-257 (2012-09-11)
Two pathogenic species within the genus Neisseria cause the diseases gonorrhoea and meningitis. While vaccines are available to protect against four N. meningitidis serogroups, there is currently no commercial vaccine to protect against serogroup B or against N. gonorrhoeae. Moreover, the available
Hypoglycosylation is a common finding in antithrombin deficiency in the absence of a SERPINC 1 gene defect
de la Morena-Barrio M E, et al.
Journal of Thrombosis and Haemostasis, 14(8), 1549-1560 (2016)
Receptor-mediated activation of a proinsulin-transferrin fusion protein in hepatoma cells.
Wang, Y., et al.
J. Controlled Release, 155, 386-392 (2011)
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