V1253
Anti-Vascular Endothelial Growth Factor antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-VEGF
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About This Item
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
capture ELISA: suitable
immunohistochemistry: suitable
neutralization: suitable
western blot: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Vegfa(22339)
General description
Vascular Endothelial Growth Factor (VEGF) is a 46kD dimeric, heparin binding glycoprotein. It facilitates several functions like induction of endothelial cell proliferation, inhibits apoptosis, induces permeabilization of blood vessels and promotes cell migration. Anti-Vascular Endothelial Growth Factor antibody can be used for neutralizing the biological activity of recombinant mouse (VEGF164) and recombinant mouse (VEGF120). It can also be used in immunoblotting. Goat anti-Vascular Endothelial Growth Factor antibody reacts specifically with recombinant mouse VEGF.
Specificity
The antibody will neutralize the biological activity of recombinant mouse VEGF164, and recombinant mouse VEGF121. It can also be used as a capture antibody in mouse VEGF 164 or 120 sandwich ELISAs.
Immunogen
purified 164 amino acid residue variant of recombinant mouse VEGF.
Application
Anti-Vascular Endothelial Growth Factor antibody can be used in sandwich ELISAs as a capture antibody in mouse VEGF 164 or 120. It can also be used in immunohistochemistry.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Johan Dixelius et al.
Cancer research, 66(4), 2089-2097 (2006-02-21)
Histidine-rich glycoprotein (HRGP) is an abundant heparin-binding plasma protein that efficiently arrests growth and vascularization of mouse tumor models. We have shown that the antiangiogenic effect of HRGP is dependent on its histidine/proline-rich domain, which needs to be released from
Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor.
J F Murphy et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(9), 1667-1669 (2001-06-28)
Jeanette Woolard et al.
Cancer research, 64(21), 7822-7835 (2004-11-03)
Growth of new blood vessels (angiogenesis), required for all tumor growth, is stimulated by the expression of vascular endothelial growth factor (VEGF). VEGF is up-regulated in all known solid tumors but also in atherosclerosis, diabetic retinopathy, arthritis, and many other
Hui Wang et al.
Cell cycle (Georgetown, Tex.), 17(17), 2164-2174 (2018-09-11)
The highly malignant feature and difficulties for early diagnosis are the key reasons contributing to the poor prognosis of pancreatic cancer (PC) patients. NFE2L3 is a nuclear transcription factor, which has been reported an important biomarker of several tumors. But
Atul Kolate et al.
Journal of controlled release : official journal of the Controlled Release Society, 192, 67-81 (2014-07-06)
Polyethylene glycol (PEG) conjugation is a rapidly evolving strategy to solve hurdles in therapeutic delivery and is being used as an add-on tool to the traditional drug delivery methods. Chemically, PEGylation is a term used to denote modification of therapeutic
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