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V4390

Sigma-Aldrich

VUF 8430 dihydrobromide

≥97% (NMR)

Synonym(s):

2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester, S-(2-guanidylethyl)-isothiourea

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About This Item

Empirical Formula (Hill Notation):
C4H11N5S· 2HBr
CAS Number:
100130-32-3
Molecular Weight:
323.05
MDL number:
MFCD01694605
UNSPSC Code:
12352200
PubChem Substance ID:
329829051
NACRES:
NA.77

Quality Level

100

assay

≥97% (NMR)

form

solid

storage condition

desiccated

solubility

deionized water: 24 mg/mL

storage temp.

room temp

SMILES string

Br.Br.NC(=N)NCCSC(N)=N

InChI

1S/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8;;/h1-2H2,(H3,7,8)(H4,5,6,9);2*1H

InChI key

GPWJSTKHQMIXCA-UHFFFAOYSA-N

Biochem/physiol Actions

VUF 8430 dihydrobromide is a potent histamine H4 receptor agonist, with a 33-fold selectivity over the histamine H3 receptor and negligible affinity for the other histamine receptor.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Tamara E Galarza et al.
Biochemical pharmacology, 180, 114177-114177 (2020-07-30)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer growth, its function in the EMT is less known. In this

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