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V9014

Sigma-Aldrich

Anti-VMAT2 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-SLC18A2, Anti-SVAT, Anti-SVMT, Anti-Solute carrier family 18 (vesicular monoamine), member 2, Anti-VAT2, Anti-VMAT2

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About This Item

MDL number:
MFCD02097601
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000

UniProt accession no.

Q05940

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SLC18A2(6571)
mouse ... Slc18a2(214084)
rat ... Slc18a2(25549)

General description

Vesicular monoamine transporter 2 (VMAT2) , also known as solute carrier family 18 member A2 (SLC18A2), is a transmembrane protein that acts at nerve terminals. It is expressed in platelets and in central, peripheral and enteric neurons. The gene encoding VMAT2 consists of 16 exons and is mapped to human chromosome 10q25.

Immunogen

synthetic peptide corresponding an internal sequence of human VMAT2. This sequence is identical in mouse and rat.

Application

Anti-VMAT2 antibody produced in rabbit has also been used in immunofluorescence.
Anti-VMAT2 antibody produced in rabbit has been used in western blot analysis.

Biochem/physiol Actions

Vesicular monoamine transporter 2 (VMAT2) modulates the release of neurotransmitters like dopamine, serotonin and γ-amino butyric acid. It has a role in the accumulation of neurotransmitters in synaptic vesicles to prevent toxicity. VMAT2 has been linked to tardive dyskinesia and may be associated with Parkinson′s disease.

Physical form

solution in phosphate buffered saline, containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Certificates of Analysis (COA)

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Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Longo F
Acta Neuropathologica Communications, 5, 22-22 (2017)
Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia.
Zai CC
Journal of Psychiatric Research, 47, 1760-1765 (2013)
N E Straznicky et al.
Obesity science & practice, 2(1), 13-23 (2016-11-05)
The objective of this study was to examine the cross-sectional relationship between the expression of norepinephrine transporter (NET), the protein responsible for neuronal uptake-1, and indices of glycaemia and hyperinsulinaemia, in overweight and obese individuals. Thirteen non-medicated, non-smoking subjects, aged
Analysis of vesicular monoamine transporter 2 polymorphisms in Parkinson's disease.
Brighina L
Neurobiology of Aging, 34, e9-13 (2013)
Vesicular monoamine transporter, type 2 (VMAT2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas.
Freeby M
Islets, 4, 393-397 (2012)
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