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WH0007273M2

Sigma-Aldrich

Monoclonal Anti-TTN antibody produced in mouse

clone 2B3, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CMD1G, Anti-CMH9, Anti-CMPD4, Anti-DKFZp451N061, Anti-FLJ32040, Anti-LGMD2J, Anti-TMD, Anti-titin

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2B3, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

GenBank accession no.

BC058824

UniProt accession no.

Q8WZ42

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TTN(7273)

Related Categories

General description

TTN (Titin) is the giant muscle protein consisting of a catalytic serine kinase domain. The gene encoding this protein is localized on human chromosome 2q31.2.

Immunogen

TTN (AAH58824, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRL

Biochem/physiol Actions

Titin (TTN) is an elastic protein that maintains cardiac muscle elasticity. S-glutathionylation of cryptic cysteines inhibits protein folding as well as disrupts mechanical stability that further increases titin elasticity through posttranslational modifications. TTN controls the temporal and spatial organizations of the striated muscle. During myofibrillogenesis, it phosphorylates the muscle protein telethonin for differentiating myocytes.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding
Jorge Alegre-Cebollada
Cell, 156 (2014)
Structural basis for activation of the titin kinase domain during myofibrillogenesi
Nature, 395 (1998)
Exome sequencing identifies a novel TTN mutation
in a family with hereditary myopathy with early
respiratory failure
Naoki Suzuki
Journal of Human Genetics (2013)

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