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PHL85771

Securinine

phyproof® Reference Substance

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About This Item

Empirical Formula (Hill Notation):
C13H15NO2
CAS Number:
5610-40-2
Molecular Weight:
217.26
MDL number:
MFCD00078775
UNSPSC Code:
41116107
NACRES:
NA.24

grade

primary reference standard

product line

phyproof® Reference Substance

assay

≥90.0% (HPLC)

form

solid

manufacturer/tradename

PhytoLab

storage temp.

2-8°C

SMILES string

O=C1O[C@@]23C[C@@H](C=CC2=C1)N4CCCC[C@H]34

InChI

1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1

InChI key

SWZMSZQQJRKFBP-WZRBSPASSA-N

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General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

wgk_germany

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
127234469
117522121
115723103
114666602

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