Y0002262
N-Nitroso-ethyl-isopropylamine
European Pharmacopoeia (EP) Reference Standard
Synonym(s):
N-Ethyl-N-nitroso-2-propanamine solution
About This Item
Recommended Products
manufacturer/tradename
EDQM
concentration
in methanol
application(s)
pharmaceutical
storage temp.
2-8°C
InChI
1S/C5H12N2O/c1-4-7(6-8)5(2)3/h5H,4H2,1-3H3
InChI key
VGGZTNNNXAUZLB-UHFFFAOYSA-N
General description
Application
It is also used to prepare N-Nitrosamines spiking solution to detect the concentration of N-nitrosamines in active substances according to the monograph 20542 of European Pharmacopoeia.
Packaging
Other Notes
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 1B - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
wgk_germany
WGK 3
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Articles
Learn about LC-MS/MS method development to quantify NDMA impurity in valsartan drug substance using Titan™ C18 column based UHPLC separation
Nitrosamines have been discovered as a serious contaminant group in active pharmaceutical ingredients (API) belonging to the sartan family. This article describes a GC-MS method for the determination of nitrosamines in Valsartan tablets according to US FDA guide lines that can be used for pharma QC.
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