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COO/COA

1091221

USP

Captopril disulfide

Name: Captopril disulfide
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₈N₂O₆S₂

CAS Number:

64806-05-9

Molecular Weight:

432.55

UNSPSC Code:

41116107

NACRES:

NA.24

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Slide 1 of 9

1 of 9

USP

1029512

Amlodipine Related Compound A

Y0000435

Captopril impurity E

Sigma-Aldrich

8.19040

Ethylenediaminetetraacetic acid dipotassium salt dihydrate

SAFC

1.06441

Sodium fluoride

USP

1708773

Valsartan Related Compound A

Y0001219

Captopril impurity B

Supelco

1.06528

Sodium disulfite

Supelco

1.05043

Potassium iodide

Sigma-Aldrich

A8887

Acrylamide

grade

pharmaceutical primary standard

API family

captopril

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C18H28N2O6S2/c1-11(15(21)19-7-3-5-13(19)17(23)24)9-27-28-10-12(2)16(22)20-8-4-6-14(20)18(25)26/h11-14H,3-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,12?,13+,14+/m1/s1

InChI key

ZWKRXBCJAUKDCI-KRCVMZOZSA-N

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Related Categories

Analytical Reference Materials for the Pharma Industry

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Captopril disulfide USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard, system suitability stock, and system suitability solution for assay and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):

Captopril Tablets
Captopril
Captopril and Hydrochlorothiazide Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Metabolism of captopril-L-cysteine, a captopril metabolite, in rats and dogs.

K J Kripalani et al.

Xenobiotica; the fate of foreign compounds in biological systems, 13(12), 701-705 (1983-12-01)

The metabolism of [14C]captopril-L-cysteine was studied in spontaneously hypertensive rats and pure-bred beagles after a single i.v. dose (4 mg/kg). During the first 24 h, concn. of total radioactivity in blood were similar in both species. Captopril was found in

Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat.

O H Drummer et al.

Biochemical pharmacology, 33(22), 3567-3571 (1984-11-15)

The absorption and metabolism of the disulfide dimer conjugate of captopril has been studied in the rat following both oral and intravenous dosing and compared with that of the active monomer, captopril. Metabolism of the dimer to captopril has been

The pharmacokinetics of captopril and captopril disulfide conjugates in uraemic patients on maintenance dialysis: comparison with patients with normal renal function.

O H Drummer et al.

European journal of clinical pharmacology, 32(3), 267-271 (1987-01-01)

We have measured the plasma concentrations of captopril and total disulfide conjugates of captopril after a 50 mg oral dose in 6 uraemic patients on maintenance dialysis and in 8 hypertensive subjects with normal renal function. The mean peak plasma

[Determination of captopril plus its disulfide metabolites in human plasma].

D Zhong et al.

Yao xue xue bao = Acta pharmaceutica Sinica, 33(8), 605-609 (2002-05-23)

A new and sensitive HPLC method has been developed for the determination of captopril plus its disulfide metabolites (total captopril) in human plasma. Captopril disulfides and the drug covalently bound to protein were reduced with sodium borohydride to captopril. After

Potentiation of bradykinin-induced decrease of blood pressure in dogs by SO 14,551, the disulfide metabolite of captopril.

N O'Hara et al.

Japanese journal of pharmacology, 32(5), 934-937 (1982-10-01)

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