Skip to Content
MilliporeSigma
All Photos(1)

Documents

1205003

USP

Diltiazem hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(+)-cis-Diltiazem hydrochloride, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C22H26N2O4S · HCl
CAS Number:
33286-22-5
Molecular Weight:
450.98
Beilstein/REAXYS Number:
4228706
MDL number:
MFCD00069252
UNSPSC Code:
41116107
PubChem Substance ID:
329749607
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

diltiazem

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O

InChI

1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

InChI key

HDRXZJPWHTXQRI-BHDTVMLSSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application


  • Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis. This study investigates the potential of carboxymethylated and crosslinked Albizia procera gum for use in sustained-release matrix tablets containing Diltiazem hydrochloride, highlighting its viability in pharmaceutical applications (Mukherjee S, Khanam J, 2024).

  • Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions. While primarily focused on gallic acid, this review mentions Diltiazem hydrochloride in the context of drug interactions and its implications in food safety and health (Xiang Z et al., 2024).

  • Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity. This research presents a novel NanoSensoGel that could be adapted for Diltiazem hydrochloride, enhancing drug delivery efficiency in clinical settings (Thakur NS et al., 2024).

  • A novel potentiometric sensor based on ZnO decorated polyaniline/coal nanocomposite for diltiazem determination. This study develops a new sensor for the precise measurement of Diltiazem levels in pharmaceutical formulations, which is crucial for quality control and regulatory compliance (El Sayed GA et al., 2023).

  • The Effect of Topical Nifedipine versus Diltiazem on the Acute Anal Fissure: A Randomized Clinical Trial. This clinical trial evaluates the effectiveness of Diltiazem hydrochloride in treating acute anal fissures, providing evidence of its beneficial applications in proctological disorders (Momayez Sanat Z et al., 2023).

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 5

1 of 5

(±)-Verapamil hydrochloride ≥99% (titration), powder

Sigma-Aldrich

V4629

(±)-Verapamil hydrochloride

Nifedipine ≥98% (HPLC), powder

Sigma-Aldrich

N7634

Nifedipine

Moxifloxacin hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1581

Moxifloxacin hydrochloride

Chloroquine phosphate United States Pharmacopeia (USP) Reference Standard

USP

1118000

Chloroquine phosphate

Lidocaine powder

Sigma-Aldrich

L7757

Lidocaine

Diltiazem hydrochloride.
B F McGraw
Drug intelligence & clinical pharmacy, 16(5), 366-370 (1982-05-01)
[Diltiazem hydrochloride: synthetic and pharmacological studies and development].
K Abe et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01)
Hossein Gandomkar et al.
Diseases of the colon and rectum, 58(2), 228-234 (2015-01-15)
The aim of this study is to evaluate the effectiveness and complications associated with combined topical diltiazem cream and botulinum toxin A injection versus partial lateral internal sphincterotomy in chronic anal fissure. This study is a parallel, randomized controlled trial
Takeshi Ogura et al.
Acta neurochirurgica. Supplement, 120, 47-50 (2014-11-05)
This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage. Of patients with aneurysmal SAH who underwent aneurysm repair between August 2008 and June 2011, 119
B J McAuley et al.
Pharmacotherapy, 2(3), 121-133 (1982-05-01)
Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service