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USP

Enalapril maleate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Enalapril maleate salt, (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt

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About This Item

Empirical Formula (Hill Notation):
C20H28N2O5 · C4H4O4
CAS Number:
76095-16-4
Molecular Weight:
492.52
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

enalapril

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@@H](C(N1[C@H](C(O)=O)CCC1)=O)N[C@H](CC(OCC)=O)CCC2=CC=CC=C2.O=C(OO)/C=C\C(O)=O

InChI

1S/C21H30N2O5.C4H4O5/c1-3-28-19(24)14-17(12-11-16-8-5-4-6-9-16)22-15(2)20(25)23-13-7-10-18(23)21(26)27;5-3(6)1-2-4(7)9-8/h4-6,8-9,15,17-18,22H,3,7,10-14H2,1-2H3,(H,26,27);1-2,8H,(H,5,6)/b;2-1-/t15-,17-,18-;/m0./s1

InChI key

UQKQUZOIQFOJOI-KJHLASMFSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Enalapril maleate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

A long-acting angiotensin-converting enzyme inhibitor.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marta de Diego et al.
Journal of chromatographic science, 52(10), 1193-1197 (2013-12-04)
A simple and rapid stability-indicating liquid chromatographic method was developed and validated for the simultaneous determination of lisinopril and hydrochlorotiazide (HCTZ) in drug substances and dosage forms in the presence of degradation products. Forced degradation studies were conducted on the
PARADIGM-HF--the experts' discussion.
Mariell Jessup et al.
The New England journal of medicine, 371(11), e15-e15 (2014-09-04)
Neprilysin inhibition--a novel therapy for heart failure.
Mariell Jessup
The New England journal of medicine, 371(11), 1062-1064 (2014-09-02)
John J V McMurray et al.
The New England journal of medicine, 371(11), 993-1004 (2014-09-02)
We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients. In this double-blind trial, we randomly assigned 8442 patients with class
Jorge Luiz Alves-Pereira et al.
The Journal of urology, 192(6), 1878-1883 (2014-06-01)
We evaluated whether antihypertensive drugs that act through the renin-angiotensin system would affect testis function. Ten mice were fed standard chow and 40 received a high energy density diet. At 8 weeks the high energy density diet mice were divided
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