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USP

Flucytosine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

5-Fluorocytosine, 4-amino-5-fluoro-2(1H)-pyrimidinone, Flucytosine

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About This Item

Empirical Formula (Hill Notation):
C4H4FN3O
CAS Number:
2022-85-7
Molecular Weight:
129.09
Beilstein/REAXYS Number:
127285
MDL number:
MFCD00006035
UNSPSC Code:
41116107
PubChem Substance ID:
329749852
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

flucytosine

manufacturer/tradename

USP

mp

298-300 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NC1=NC(=O)NC=C1F

InChI

1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)

InChI key

XRECTZIEBJDKEO-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flucytosine USP reference standard for use in specified quality tests and assays.

Also used to prepare standard and sensitivity solutions for the assay, identification, performance test, and impurity analysis according to the given below monographs of United States Pharmacopeia (USP):
  • Flucytosine
  • Flucytosine Capsules
  • Flucytosine Compounded Oral Suspension

Biochem/physiol Actions

Nucleoside analog that has antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. 5-Fluorocytosine inhibits DNA and RNA synthesis and interferes with ribosomal protein synthesis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361

pcodes

P280

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Flucytosine Capsules
United States Pharmacopeia, 46(5) (2022)
Flucytosine
United States Pharmacopeia, 46(5) (2022)

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