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1366002

USP

Lidocaine

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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About This Item

Empirical Formula (Hill Notation):
C14H22N2O
CAS Number:
137-58-6
Molecular Weight:
234.34
MDL number:
MFCD00026733
UNSPSC Code:
41116107
PubChem Substance ID:
329750054
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

lidocaine

manufacturer/tradename

USP

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Lidocaine USP reference standard for use in specified quality tests and assays.

Also used to prepare standard and system suitability solution for assay, identification and impurity analysis according to given below monographs of the United States Pharmacopeia (USP):
  • Lidocaine
  • Lidocaine Hydrochloride Topical Solution
  • Lidocaine Hydrochloride Oral Topical Solution
  • Lidocaine Hydrochloride Jelly

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Description
Pricing

L0595000

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L0600000

Lidocaine hydrochloride, European Pharmacopoeia (EP) Reference Standard

PHR1257

Lidocaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1669

Lidocaine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1671

Lidocaine Related Compound C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1673

Lidocaine Related Compound H, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1670

Lidocaine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1672

Lidocaine Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1674

Lidocaine Related Compound I, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1675

Lidocaine Related Compound J, Pharmaceutical Secondary Standard; Certified Reference Material

1366080

Lidocaine Related Compound H, United States Pharmacopeia (USP) Reference Standard

1366013

Lidocaine hydrochloride, United States Pharmacopeia (USP) Reference Standard

BP727

Lidocaine, British Pharmacopoeia (BP) Reference Standard

BP214

Lidocaine hydrochloride, British Pharmacopoeia (BP) Reference Standard

PHR1995

Lidocaine Impurity G, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1994

Lidocaine Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lidocaine Related Compound H United States Pharmacopeia (USP) Reference Standard

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1366080

Lidocaine Related Compound H

Lidocaine solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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L-018

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1561008

Prilocaine hydrochloride

USP

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1605512

Ropivacaine Related Compound A

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Supelco

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Lidocaine Related Compound H Pharmaceutical Secondary Standard; Certified Reference Material

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1432005

Methylparaben

Benzyl alcohol United States Pharmacopeia (USP) Reference Standard

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1061901

Benzyl alcohol

Lidocaine Hydrochloride Oral Topical Solution
United States Pharmacopeia, 44(4), 2626-2626 (2020)
Lidocaine Hydrochloride Jelly
United States Pharmacopeia, 43(6), 2625-2625 (2020)
Daniela Casoni et al.
Veterinary anaesthesia and analgesia, 42(3), 250-259 (2014-07-22)
To determine the potency ratio between S-ketamine and racemic ketamine as inductive agents for achieving tracheal intubation in dogs. Prospective, randomized, 'blinded', clinical trial conducted in two consecutive phases. 112 client-owned dogs (ASA I or II). All animals were premedicated
Bartholomeus C M Benno Haarman et al.
Brain, behavior, and immunity, 40, 219-225 (2014-04-08)
The "monocyte-T-cell theory of mood disorders" regards neuroinflammation, i.e. marked activation of microglia, as a driving force in bipolar disorder. Microglia activation can be visualized in vivo using [(11)C]-(R)-PK11195 PET. Indirect evidence suggests the hippocampus as a potential focus of
Song-Young Park et al.
American journal of physiology. Heart and circulatory physiology, 307(3), H346-H352 (2014-06-08)
Unlike cardiac and skeletal muscle, little is known about vascular smooth muscle mitochondrial respiration. Therefore, the present study examined mitochondrial respiratory rates in smooth muscle of healthy human feed arteries and compared with that of healthy cardiac and skeletal muscles.
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Articles

LC/MS Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC

The benefit of HILIC over traditional reversed-phase chromatography is two-fold for both sample introduction and analyte detection. First, the high acetonitrile concentration of HILIC mobile phases allows for direct analysis of precipitated plasma samples without the need for additional sample solvent exchange. Second, the high acetonitrile content provides increased analyte response in positive ESI MS detection.

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LC/MS (TOF) Analysis of Antiarrhythmic Drugs and Metabolites on Ascentis® Express HILIC

HILIC mobile phases consist of a high composition of acetonitrile, which facilitates the direct analysis of precipitated plasma samples without the need for additional sample solvent exchange.

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