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254886

Sigma-Aldrich

6,7-Dimethoxycoumarin

98%

Synonym(s):

6,7-Dimethylesculetin, O-Methylisoscopoletin, O-Methylscopoletin, Aesculetin dimethyl ether, Escoparone, Esculetin 6,7-dimethyl ether, Scoparone, Scopoletin methyl ether

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About This Item

Empirical Formula (Hill Notation):
C11H10O4
CAS Number:
120-08-1
Molecular Weight:
206.19
EC Number:
204-369-0
MDL number:
MFCD00006871
UNSPSC Code:
12352100
PubChem Substance ID:
24855271
NACRES:
NA.22

Quality Level

200

assay

98%

form

powder

mp

143-145 °C (lit.)

SMILES string

COc1cc2OC(=O)C=Cc2cc1OC

InChI

1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

InChI key

GUAFOGOEJLSQBT-UHFFFAOYSA-N

Gene Information

mouse ... Maoa(17161)
rat ... Aldh1a2(116676)

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General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Journal of chromatographic science, 45(8), 544-548 (2007-11-21)
A simple and sensitive reversed-phase high-performance liquid chromatography method with UV detection is developed and validated for the determination of 6,7-dimethoxycoumarin in rat plasma and comparative analysis of its pharmacokinetics after intragastric administration of 6,7-dimethoxycoumarin and three different decoctions of
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