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394912

Supelco

Heptafluorobutyric anhydride

for GC derivatization, LiChropur™, ≥99.0%

Synonym(s):

HFBA, HFAA, Perfluorobutyric anhydride

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About This Item

Linear Formula:
(CF3CF2CF2CO)2O
CAS Number:
336-59-4
Molecular Weight:
410.06
Beilstein/REAXYS Number:
856036
EC Number:
206-410-8
MDL number:
MFCD00000432
UNSPSC Code:
12000000
PubChem Substance ID:
24864629
NACRES:
NA.22

grade

for GC derivatization

Quality Level

100

assay

≥99.0%

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.287 (lit.)

bp

108-110 °C (lit.)

mp

−43 °C (lit.)

density

1.674 g/mL at 20 °C (lit.)

SMILES string

FC(F)(F)C(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)C(F)(F)F

InChI

1S/C8F14O3/c9-3(10,5(13,14)7(17,18)19)1(23)25-2(24)4(11,12)6(15,16)8(20,21)22

InChI key

UFFSXJKVKBQEHC-UHFFFAOYSA-N

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Related Categories

General description

Heptafluorobutyric anhydride (HFB) is a derivatizing reagent. It provides facile and sensitive way for detecting and elucidating structure of numerous alkyl-chain homologs.

Application

Learn more in the Product Information
GC derivatizing agent used to prepare volatile derivatives of amino acids and other biologically active compounds.
HFB was used as derivatizing agent in analysing platelet-activating factor using GC-MS.
Suitable for the derivatization of aldosterone, digoxin, digitoxin and metabolites, estradiol, postaglandins F1α and F2α, 3-oxo-Δ4-steroids, and testosterone.

Packaging

Derivatization reagent used in a GC-MS analysis of stereoisomer content of synthetic peptides.

Other Notes

Reagent for heptafluorobutyrate, 3-enol heptafluorobutyrate, 17-heptafluorobutyrate, heptafluorobutyrate and heptafluorobutyryl.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

accessory

Product No.
Description
Pricing

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Skin Corr. 1B

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sigma-Aldrich

8.43443

Heptafluorobutyric acid

S T Weintraub et al.
Journal of lipid research, 31(4), 719-725 (1990-04-01)
Parallel analysis of platelet-activating factor (PAF) using chemical ionization gas chromatography-mass spectrometry after direct derivatization with pentafluorobenzoyl chloride (PFB) and heptafluorobutyric anhydride (HFB) provides a facile and highly sensitive means for detecting and elucidating the structure of the numerous alkyl-chain
J Bakthavachalam et al.
Journal of chromatography, 500, 373-386 (1990-02-02)
Several electrophoric derivatives of 1-aminopyrene and 2-aminofluorene were prepared. Reagents such as heptafluorobutyryl chloride, pentafluorobenzoyl chloride, pentafluorobenzyl bromide and pentafluorobenzaldehyde, alone and in certain combinations, were employed. The ease of formation, yield, stability and fragmentation by gas chromatography with electron-capture
Ralf Pätzold et al.
Chirality, 18(7), 551-557 (2006-05-10)
Synthetic dipeptides comprising mixtures of enantiomers, diastereomers, or sequential isomers were converted into their N-perfluoroacetyl dipeptide esters (perfluoroacetyl: trifluoroacetyl, pentafluoroacetyl, heptafluorobutyryl; ester: methyl, 1-propyl, 2-propyl, 2,2,2-trifluoroethyl) and analyzed by GC-MS on the chiral stationary phases Chirasil-L-Val and Lipodex-E using helium
C Fakt et al.
Journal of chromatography. B, Biomedical sciences and applications, 700(1-2), 93-100 (1997-12-09)
A convenient and sensitive method for the quantitative determination of poly(ethylene glycol) 400 in plasma and urine with capillary gas chromatography-mass spectrometry has been developed. The sample preparation involves solid-phase extraction with subsequent derivatization with heptafluorobutyric anhydride, which proved to
Oliver Lerch et al.
Journal of chromatography. A, 991(1), 77-97 (2003-04-22)
Methods for ultra trace detection of endocrine disruptive chemicals (EDCs) are needed because of their low levels of impact. Twenty-one EDCs were selected, including 17beta-estradiol, 17alpha-ethinylestradiol, 17beta-testosterone and bisphenol A. Derivatisation with eight different fluorine containing compounds was examined. All
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