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Sigma-Aldrich

Poly(N-isopropylacrylamide), carboxylic acid terminated

average Mn 2,000

Synonym(s):

NIPAM polymer, PNIPAM-COOH, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM

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About This Item

Linear Formula:
(C6H11NO)nSCH2CH2CO2H
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder

Quality Level

mol wt

average Mn 2,000

mp

>300 °C

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Application

Novel polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Articles

Poly(N-isopropylacrylamide), or PNIPAM, is a stimuli-responsive polymer that responds to changes in pH and temperature and has a LCST around 32 C.

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.

By altering the physicochemical properties, smart or intelligent drug delivery systems can be designed to deliver therapeutic molecules on-demand. Learn more about the application of stimuli-responsive materials in drug delivery.

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization via "living" polymerization such as RAFT, ionic and ring opening polymerization. Selected polymers have been studied for their structure-properties relationship. "

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