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740292

Sigma-Aldrich

Vitamin D3 solution

100 μg/mL in ethanol, 97% (CP)

Synonym(s):

Cholecalciferol solution

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About This Item

Empirical Formula (Hill Notation):
C27H44O
CAS Number:
67-97-0
Molecular Weight:
384.64
EC Number:
200-578-6
MDL number:
MFCD00078131
UNSPSC Code:
41116107
eCl@ss:
34058003
PubChem Substance ID:
329765397
NACRES:
NA.24

Quality Level

200

assay

97% (CP)

form

solution

concentration

100 μg/mL in ethanol

technique(s)

mass spectrometry (MS): suitable

color

colorless

mp

-144.0 °C

application(s)

detection

storage temp.

−20°C

SMILES string

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

InChI key

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Gene Information

human ... VDR(7421)

Related Categories

General description

Vitamin D3 is also known as cholecalciferol which promotes the absorption of calcium and phosphorus in the body that regulates bone growth. It is commonly found in humans and animals produced on our skin when exposed to sunlight. It facilitates bone growth and mineralization indirectly by enhancing plasma calcium and phosphorus levels. It is synthesized from 7-dehydrocholesterol, a derivative of cholesterol.

Application

Vitamin D3 is used as an internal analytical standard for the quantitation of vitamin D3 concentration in dietary supplements, fortified foods or within a complex biological matrix using a variety of testing applications.
The active metabolite of vitamin D3 is calcitriol (1,25-dihydroxyvitamin D3) encapsulated into polymeric nanoparticles, which finds the application in vitamin D3-based chemotherapy formulation study and in vitro evaluation.

Packaging

1 mL in ampule

related product

Product No.
Description
Pricing

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

hcodes

H225,H319

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2

wgk_germany

WGK 1

flash_point_f

57.2 °F

flash_point_c

14.0 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cholecalciferol meets USP testing specifications

Sigma-Aldrich

C1357

Cholecalciferol

Cholecalciferol United States Pharmacopeia (USP) Reference Standard

USP

1131009

Cholecalciferol

Vitamin D2 solution 1 mg/mL in ethanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-024

Vitamin D2 solution

Vitamin D3, 1α, 25-Dihydroxy- CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

Millipore

679101

Vitamin D3, 1α, 25-Dihydroxy-

Cholecalciferol European Pharmacopoeia (EP) Reference Standard

C2100000

Cholecalciferol

Vitamin D3, 25-Hydroxy- Metabolite of vitamin D3 via a single cytochrome P450-mediated hydroxylation.

Millipore

679102

Vitamin D3, 25-Hydroxy-

USP

USP

1717504

Vitamin D Assay System Suitability

Nano-encapsulation of vitamin D 3 active metabolites for application in chemotherapy: formulation study and in vitro evaluation
Almouazen E, et al.
Pharmaceutical Research, 30(4), 1137-1146 (2013)
Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin
Holick, MF, et al.
Biochemical and biophysical research communications, 76(1), 107-114 (1977)
Stefan Pilz et al.
Hypertension (Dallas, Tex. : 1979), 65(6), 1195-1201 (2015-03-25)
Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values
Anders Burild et al.
Steroids, 98, 72-79 (2015-03-01)
Information regarding the endogenous storages of vitamin D3 after cutaneous vitamin D synthesis compared to oral vitamin D3 supplementation is sparse. Furthermore it is not known whether vitamin D3 can be stored for later use during periods of shortages of
Vitamin D is not directly necessary for bone growth and mineralization
Underwood JL and DeLuca HF
American Journal of Physiology. Endocrinology and Metabolism, 246(6), E493-E498 (1984)
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