679101
Vitamin D3, 1α, 25-Dihydroxy-
CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.
Synonym(s):
Vitamin D3, 1α, 25-Dihydroxy-, 1,25-(OH)₂-D₃, Calcitriol
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About This Item
Empirical Formula (Hill Notation):
C27H44O3
CAS Number:
Molecular Weight:
416.64
MDL number:
UNSPSC Code:
12352205
Recommended Products
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
solubility
DMSO: 50 mg/mL
ethanol: soluble
shipped in
wet ice
storage temp.
−70°C
InChI
1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key
GMRQFYUYWCNGIN-NKMMMXOESA-N
Related Categories
General description
Active hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D3. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca2+ and phosphate transport and mobilizes Ca2+ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
Application
- Vitamin D deficiency or resistance and hypophosphatemia.: Discusses the complex interplay between vitamin D metabolism and phosphate homeostasis, emphasizing the crucial role of 1α,25-Dihydroxy-vitamin D3 in managing and understanding bone mineral disorders and their systemic implications (Sarathi et al., 2024).
- Altered Expression of Vitamin D Metabolism Genes and Circulating MicroRNAs in PBMCs of Patients with Type 1 Diabetes.: Investigates how 1α,25-Dihydroxy-vitamin D3 influences gene expression and microRNA profiles in peripheral blood mononuclear cells, linking vitamin D status with autoimmune processes in diabetes (Al-Nakhle et al., 2023).
- 1α,25-Dihydroxyvitamin D(3) Improves Follicular Development and Steroid Hormone Biosynthesis by Regulating Vitamin D Receptor in the Layers Model.: Demonstrates the role of 1α,25-Dihydroxy-vitamin D3 in enhancing reproductive functions and hormonal balance through its action on the vitamin D receptor, providing insights into fertility management (Cheng et al., 2023).
- 1α,25(OH)(2)D(3) Promotes the Autophagy of Porcine Ovarian Granulosa Cells as a Protective Mechanism against ROS through the BNIP3/PINK1 Pathway.: This study presents the protective effects of 1α,25-Dihydroxy-vitamin D3 on ovarian cells under oxidative stress, suggesting mechanisms that could be exploited for therapeutic interventions in reproductive health (Wang et al., 2023).
Packaging
Packaged under inert gas
Warning
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
Reconstitution
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem.269, 3125.
Mathieu, C., et al. 1994. Diabetologica37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem.266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun.176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun.176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun.166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem.264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem.52, 411.
Hannun, Y.A. 1994. J. Biol. Chem.269, 3125.
Mathieu, C., et al. 1994. Diabetologica37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem.266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun.176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun.176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun.166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem.264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem.52, 411.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1
Storage Class
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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